The Laan lab is located in the Department of Bionanoscience, part of the Kavli Institute of Nanoscience at the Delft University of Technology. We are fascinated by how interactions between biomolecules give rise to living matter, alias life. Physical and chemical laws are the same for living and non living matter, so what is it about the organization of a cell that makes it alive?

We know that cells are highly organized in space and time. During mitosis for example, an intricate network of interactions ensures a remarkable precision and robustness in DNA segregation. This network is highly dynamic and self-organizing; it disassembles at one phase during the cell cycle to be completely rebuilt in the next phase. Additionally this network needs to be robust against genetic perturbations. Especially large multi-cellular organisms, which acquire mutations during their lifetime need to buffer against spontaneous mutations to avoid, for example, cancer formation. Nevertheless, on long evolutionary timescales mutations are essential since they allow organisms to adapt to their changing environment. So how do these complex networks manage to be robust and highly organized on short cellular timescales, but also adaptable on long evolutionary timescales?

image by Andreu Tabener


December 8th: Albert and Pim join our lab for their nanobiology minor, welcome!

December 2017: Enzo, Christine and Els start as PhD students in our lab, welcome!

October 30th: Liedewij is invited by the students for a seminar of the biochemistry department at Oxford University in the UK.

October 17th: Our paper about chromosome loss in cells of different ploidy together with the group of Nenad Pavin is now on the BioRxiv!

September 11th: Nice piece in delta about our research.

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We answer these questions using a variety of experimental approaches ranging from physics to evolutionary biology. To achieve a deeper understanding of our systems we combine our experiments with modelling approaches, often in collaboration with theory groups.

We have open Post-doc positions